Volume 38
Number 1 January 2025Successful Pregnancy after Chemotherapy for Ovarian Yolk Sac Tumor
DOI: https://doi.org/10.47648/jmsr.2025.v3801.06
Nessa M1 , Ahmed N2 , Begum F3 , Sarker A4 , Karim F5 , Salehin S6
Abstract
Background: Ovarian yolk sac tumors are rare malignant germ cell tumors in young women. Fertility-sparing surgery plus bleomycin, etoposide, and cisplatin chemotherapy improves survival. Documented reports of term pregnancies after treatment are rare. Case Findings: A 29-yearold woman with a history of left ovarian yolk sac tumor underwent laparotomy with bilateral ovarian cystectomy. uterus and fallopian tubes were preserved. Tumor markers included CA 125 110.04 U/mL and total β hCG 84.57 mIU/mL on 4 March 2021, followed by CA 125 38.0 U/mL, β hCG 0.8 mIU/mL, LDH 244 U/L, and AFP 1150 ng/mL on 25 March 2021. Adjuvant BEP chemotherapy was administered as four 3 weekly cycles on 15 April 2021, 8 May 2021, 4 June 2021, and 24 June 2021, with completion of treatment on 1 July 2021. Whole body 18F-FDG PET/CT on 8 August 2021 showed no evidence of recurrence. She conceived in 2022. Antenatal ultrasonography demonstrated a single live intrauterine pregnancy with normal anatomy and Doppler findings. Outcome: At 38 plus weeks on 22 November 2022, she delivered by elective lower segment cesarean section a healthy female neonate weighing 3.2 kg, Apgar scores 8 and 9. Omental biopsy taken at cesarean was negative for metastasis. Conclusion: This case shows successful term pregnancy after fertilitysparing surgery and BEP chemotherapy for ovarian yolk sac tumor, with disease-free surveillance and negative intraoperative biopsy.
Keywords:
- Professor and Head of Department, Department of Gynecology
- Professor, Department of Gynecology
- Associate Professor, Department of Gynecology
- Academic Registrar, Department of Gynecology
- Registrar,Department of Gynecology
- MBBS Student