Introduction: Acute viral encephalitis (AVE) is a severe neurological condition associated with significant morbidity and mortality, often caused by neurotropic viruses such as herpes simplex virus (HSV) and Japanese encephalitis virus (JEV). Early recognition is challenging due to overlapping clinical features with other central nervous system disorders and variable laboratory and imaging findings. Objective: To describe the demographic characteristics, clinical presentations, neuroimaging findings, and cerebrospinal fluid (CSF) parameters of patients with clinically suspected AVE in a tertiary care hospital in Bangladesh. Methods: This observational study was carried out at the Department of Neurology during December-2024 to November-2025 in, Chittagong Medical College Hospital (CMCH), Chattogram, Bangladesh. A total of 93 patients irrespective of age and sex with clinically suspected acute viral encephalitis (AVE) were consecutively enrolled during the study period. Clinical evaluation, laboratory investigations, MRI, and CSF analysis were performed for all patients. Data were analyzed usingStatistical Package for Social Sciences(SPSS) version 23.0.Ethical approval for the study was obtained from the Institutional Review Board (IRB) of Chittagong Medical College, and confidentiality of all patients’ information was strictly maintained throughout the research process in accordance with the Declaration of Helsinki-1964. Results: The mean age of the study patients was 45.87 ± 20.13 years, with nearly equal gender distribution (52.7% male). Fever (100%) and altered consciousness (96.8%) were the most common clinical features, followed by confusion (80.7%), headache (54.8%), and vomiting (51.6%). MRI abnormalities were observed in 52.7% of patients, including restricted diffusion (50.5%), FLAIR T2 changes (50.5%), and hypodense areas of hypoxia (43%). Focal neurological deficits were present in 22.6% patients, and extensor plantar response predominated in (65.6%) patients. CSF analysis revealed a median glucose of 78 mg/dL, CSF/blood glucose ratio of 0.54, protein 53.7 mg/dL, RBC count 550 cells/μL, leukocyte count 8 cells/μL, neutrophils 10%, and lymphocytes 98%. Conclusion: Patients with suspected AVE in this setting presented with non-specific but severe neurological manifestations, with approximately half showing MRI abnormalities. CSF analysis provided supportive evidence of viral etiology, emphasizing the importance of integrating clinical, imaging, and laboratory data for early diagnosis and management.