It is necessary toassess the hypercoagulability and the risk of thromboembolism in women taking oral contraceptive pill (OCP) for prolonged period of time.So, we need to know the hemostatic changes that are occurring in Bangladeshi women taking OCP for prolonged period of time. This cross sectional study was done in the department of Physiology, Dhaka Medical College, Dhaka from Jan 2012 to Dec 2012. Ninety female subjects with the age range from 25-45 years, were taken as a study population. Among them, 60 women taking oral contraceptives for prolonged period of time ( >1 years) were included for the study group and age matched 30 women of OCP nonusers were taken as a control . Study subjects were divided into two group according to their duration of oral pill use: group B-1 ( 1 to 5 years users) were 30 women and group B-2 ( >5 to 10 years users) were 30 women.For assessment of hypercoagulable state total counts of platelet levels were estimated in all groups. Statistical analysis was done by unpaired Student’s 't' test and Pearson’s Correlation Coefficient test. In this studythe mean (+/-SD) total count of platelet level was higher in study group (who were taking OCP-s) than control group (OCP nonusers) which was statistically highly significant (P<0.001). Total count of platelet levels were positively correlated (r= +0.155) with the 1 to 5 years user group and negatively correlated (r= -0.019) with the >5 to 10 years user group. But all the relationships were statistically non-significant. My present study revealed that prolonged duration of OCP use ( at least 5 years) may increase the risk of thromboembolic effects.This study concludes that OCP users had more tendency of hypercoagulability and therefore this women are at higher risk of thromboembolic effects.