Volume 35
Number 2 July 2023Immunoexpression of Ki-67 and p53 in Different Grades of Astrocytoma
DOI: https://doi.org/10.47648/jmsr.2023.v3502.01
Mohammad Rabiul Haque1 , Md. Zahid Hossain2 , Alimul Hasan3 , Md. Fakhrul Hassan4 , Khadiza Khanam5
Abstract
Astrocytomas are the most common intrinsic tumors of the central nervous system and derive from astrocytes.Ki-67 and p53 are two cellular proteins that have roles in pathogenesis and evolution of astrocytomas. Ki-67 is a nuclear non-histone protein produced by cells in the proliferative phases, and the Ki-67 proliferativeindex quantitatively reflects the growth potential of tumors, making it a significant biological marker. p53is a nuclear protein that controls cell cycle, apoptosis, and genomic stability. Assessment of Ki-67 and p53in various grades of astrocytoma can aid as an ancillary tool in understanding tumor behavior. This cross-sectional type of descriptive study was carried out at the Department of Pathology, RMC, Rajshahi, andBSMMU, Dhaka, over two years, between January 2021 and December 2022. In this study, a total of 30astrocytoma cases that were histologically diagnosed were included. Ki-67 and p53 immunostaining was doneon formalin-fixed paraffin-embedded tissue blocks of all cases and compared with WHO histological gradingof astrocytomas. Both biomarkers were directly associated with each other and the grade of astrocytoma.Statistically significant differences in Ki-67 LI and p53 LI were seen between grade I and grade IV andbetween grade II and IV. However, there was no statistically significant difference between grades I and II,grades I and III, or grades II and III. These markers can aid as an ancillary tool in understanding tumorbehavior and progression.
Keywords: Astrocytoma, Ki-67, p53
- Assistant Professor, Department of Pathology
- Clinical Pathologist, Department of Pathology
- Clinical Pathologist, Department of Pathology
- Lecturer, Department of Pathology
- Professor & Head, Department of Pathology