Astrocytomas are considered the most prevalent central nervous system tumors and originate from astrocytes.According to the WHO classification, Astrocytomas are divided into four histopathological grades based oncellular atypia, mitotic rate, vascular changes, and necrosis.1 Proper astrocytoma grading helps neurosurgeonsand neuro-oncologists treat and assess the overall prognosis properly. Numerous studies have relied on variousfactors, ranging from tumor suppressor genes to proliferation markers, to gain insights into tumor behavior.Ki-67 and p53 are two cellular proteins that have roles in the pathogenesis and progression of astrocytoma.