Evaluation of Gastro-protective Activity of Red-cabbage Against Indomethacin Induced Ulcer in Rats

DOI: https://doi.org/10.47648/jmsr.2022.v3302.05

Umma Taj Lovely1 , Md. Faizul Ahasan2 , Eliza Omar3

Abstract

Background and objective: The red cabbage (Brassica oleracea Linn var. capitata) is a leafy green biennialplant that contains beta-carotene, vitamin C and fibre. It is used in cooking for its nutritional value andhas known anti-inflammatory activity.This study compared the antiulcerogenic activity of Aqueous Extractof Brassica (AEB) oleracea var. capitata with Misoprostol.Materials and Method: Acute gastric ulcers wereinduced in albino rats by the oral administration of indomethacin. The gastroprotective potential of theAEB(250,500 and 1000 mg/kg body weight) was compared with Misoprostol (100μg/kg body weight). Results:Asignificant reduction in the mean number of lesions was observed in high dose AEB (0.83 ± 0.75) comparedwith indomethacin (4.00 ± 1.26). Mean number of lesions were similar in misoprostol groups (1.50 ± 0.55)and medium dose AEB (1.77 ± 0.41).No significant reduction in the mean number of lesions was observed inlow dose AEB (3.00 ± 0.63) compared with indomethacin (4.00 ± 1.26). Inhibition percentage was maximumin high dose AEB (97.71%) and minimum in low dose AEB (28.08%).Conclusions: The AEB demonstratedgood antiulcerogenic activities which justify the inclusion of this plant in the management of gastric disorders.Further experiments are underway to determine which anti-ulcer mechanisms involved in gastroprotection.

Keywords: Anti-ulcer agents, Stomach ulcer, Brassica, Rats.


  1. Associate Professor, Department of Pharmacology

    Shahabuddin Medical College, Dhaka

  2. Assistant Professor, Department of Pharmacology

    Ibrahim Medical College, Dhaka

  3. Professor and Head, Department of Pharmacology

    Shaheed Suhrawardy Medical College, Dhaka


Volume 33, Number 2 July 2022
Page: 30-33