Volume 21

Number 2 July 2013

Effect of Neoadjuvant Chemotherapy on the Size of Lesion in Oral Squamous Cell Carcinoma

DOI: https://doi.org/10.47648/jmsr.2013.v2102.02

Sultana N1 , Rahman Q B2 , Alam S3 , Karim Md. M4 , Kabir Md. F5

Abstract

A prospective randomized trial was performed to evaluate the combination of neoadjuvant chemotherapy in patient with oral squamous cell carcinoma. Prognosis of patient with squamous cell carcinoma in oral cavity is worth improving. Chemotherapy has been reported specially active in oral cavity tumour. It has been enrolling patients with stage T2, T3, T4 NO NI N2 MO untreated squamous cell carcinoma in oral cavity. Number of patients in this study was 25, suffering from squamous cell carcinoma. This study was a Prospective study conducted among the randomly selected 25 cases of histopathologically diagnosed Squamous cell carcinoma patients from the Department of Oral and Maxillofacial surgery Bangabandhu Sheikh Mujib Medical University and Department of Oncology Bangabandhu Shiekh Mujib Medical university . Both male and female were included and assigned for three cycles of cisplatin and 5fluorouracil followed by definitive treatment. The study was done between January 2007 to December 2008. 25 patients were included in this study, 21.7% patients showed complete response and 84.2% showed partial response. Out of 25, 20.0% patients mouth opening were reduced and 4.0% patients mouth opening were improved. After taking computed tomography all patient showed tumour progression. Histopathologically only 1 patient showed complete response among 25 which is not signcant. Neoadjuvant chemotherapy reduced the size of the lesion clinically. Results down staging of the tumour but histologically it was not given any significant changes. So probably neoadjuvant chemotherapy is unable to fulfill our desire expectation.

Keywords:


  1. Assistant Professor and Head, Department Of Oral and Maxillo-facial Surgery

    MARKS Medical College & Hospital, Mirpur, Dhaka

  2. Associate Professor and Chairman, Department Oral & Maxillofacial Surgery

    Bangabandhu Sheikh Mujib Medical University, Dhaka

  3. Associate Professor and Chairman, Department of Oncology

    Bangabandhu Sheikh Mujib Medical University, Dhaka

  4. Lecturer, Department Of Oral and Maxillo-facial Surgery

    MARKS Medical College & Hospital, Mirpur, Dhaka

  5. Senior Medical Officer, Department of Otolaryngology

    Dhaka National Medical College Hospital

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Volume 21, Number 2 July 2013
Page: 45186