Main aim in neuro<amesdresia is to provide adequate tissue peoftaion to the brain to that the regional metabolic demand is met and adequate surgical crooditiatts are provided. Neuroanaesthetic peed are for.Hutgeny of intracranial space occupying lesion (ICSOL)is a major component of neuroanaesthesia. Abom 60% of all brain wows are primary and sitpreaentariat Aim of this, tudy was to absent. the effect of and Nonidine wt buraoperatim mean Maud pressure stability in craniotomy patients. This was a comparathr analytical study. Place of study was Department of Anaesthesia. Analgesia and buenshv Care Unit, Bar:gabardine Sheikh Muhl, Medical University. Shahltagh, Dhaka and duration of the .study tors my, years. Total number of patient, was 60. They were divided into two group, Group— A consisted of coarrol patients there clunidine was not used. Group — B was consisted of all 30 patients for whom denddine was used per.operatively in addition to other traditional drugs. Parameters were checked am! reestrded at the time of taking oral donidine, during induction, intabation. positioning (Moyftel head pin local infiltration. at the time of skin incision, Burr hole and duty! incisiont and then hourly. The mean pressure of the experimental group decreased steadily ilmoughout the peroperathv period, while that of the animal group took on a ohne= up to local infiltration and thereafter it began to increase and peaked mahout 107 nun of Fig at the time of Burr hale and them gradually declined to 91 MI of Hg at 60 minutes after darn opening. The data showed that the fanner group 11ax relatively stable compared to the Inter fp < 0.051.